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August 22, 2025Open Access

Causal Inference of Metabolic Syndrome on Calcific Aortic Valve Stenosis: Linkage Disequilibrium Score Regression and Two-Sample, Two-Step Mendelian Randomization Analysis

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Authors

SYShu YangZBZhiqiang BaiXYXiangqing Ye

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Overview

Observational analysis shows a causal connection between metabolic syndrome and calcific aortic valve stenosis, indicating shared genetic factors.

Key Points

  • Metabolic syndrome increases the risk of calcific aortic valve stenosis, showing a positive correlation with several risk factors.
  • LDSC analysis demonstrated significant genetic correlation (rg = 0.264, p = 4.61×10–26) between metabolic syndrome and calcific aortic valve stenosis.
  • Two-sample Mendelian randomization revealed multiple mediators involving triglycerides and waist circumference associated with CAVS.
  • This analysis implies distinct causal pathways link metabolic syndrome and calcific aortic valve stenosis, detailing their shared genetic architecture.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/68af541fad7bf08b1eadbaa0https://doi.org/10.21203/rs.3.rs-7141693/v1
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Causal inference and mediating pathways of metabolic syndrome on calcific aortic valve stenosis: linkage disequilibrium score regression and two-sample, two-step mendelian randomization study2026
  2. 2Causality of the Metabolic Syndrome and its Ingredients on Cardiovascular Disease: A Two-sample Mendelian Randomization Analysis2026
  3. 3Type 2 Diabetes, Circulating Metabolites, and Calcific Aortic Valve Stenosis: A Mendelian Randomization Study2024 · 1 citations
  4. 4The association of metabolic syndrome with aortic aneurysm: a two-sample Mendelian randomization study2025
  5. 5Assessing the causal relationship between metabolic biomarkers and coronary artery disease by Mendelian randomization studies2024 · 6 citations