Supplementary Fig. S26 from Genomic Analyses Reveal the Evolving Characteristics of Intestinal Metaplasia and Gastric Cancer

Key Points

Intestinal metaplasia develops key traits associated with gastric cancer, highlighting critical pathways involved.
Analysis of protein changes focuses on SMAD4, FBXW7, and RHOA, revealing their roles in cancer progression.
The approach includes phylogenetic tree analysis of genetic mutations, linking evolutionary changes in cancer.
Understanding these alterations could lead to novel prevention strategies and targeted therapies for gastric cancer.

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Genomic analysis reveals evolving protein changes in intestinal metaplasia and gastric cancer, suggesting new insights into their development.

Schematics of protein changes and phylogenetic tree of SMAD4, FBXW7, and RHOA.

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Xu et al. (2025) studied this question.

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