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August 15, 2025Open Access

Figure S8 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer

Xiangyu Gong Noriyoshi Ogino M. Fátima Leite Dingyao Zhang Zehua Chen Ryan Y. Nguyen Raymond Liu Emma Kruglov Kaitlin M. Flores Aidan T. Cabral Gabriel Moreira de M. Mendes Barbara E. Ehrlich Michael Mak

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Key Points

Compression of liver cancer cells leads to increased resistance to apoptosis, promoting invasiveness.
Survival analysis of liver cancer patients indicates significant associations with gene expressions under compression.
Gene expression responses were evaluated in HepG2 cells exposed to volumetric compression, revealing adaptive mechanisms.
Findings highlight the potential for therapeutic strategies targeting invasive phenotypes in liver cancer.

Implication

Investigation shows apoptosis resistance linked with volumetric compression in HepG2 cells, suggesting new cancer treatments.

Abstract

Gene expressions of ITPRs in HepG2 under compression and TCGA survival analysis on liver cancer patients.

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Cite This Study

Gong et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd256 https://doi.org/10.1158/0008-5472.29919131

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S19 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
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4Figure S11 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
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