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August 15, 2025Open Access

Figure S9 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer

Xiangyu Gong Noriyoshi Ogino M. Fátima Leite Dingyao Zhang Zehua Chen Ryan Y. Nguyen Raymond Liu Emma Kruglov Kaitlin M. Flores Aidan T. Cabral Gabriel Moreira de M. Mendes Barbara E. Ehrlich Michael Mak

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Key Points

Invasive phenotype is driven by volumetric compression in liver cancer cells, enhancing their survival.
Key evidence indicates that hepatocellular carcinoma cells develop resistance to apoptosis under compressive conditions.
Analysis involves assessing the responses of the liver cancer cell line Hep3B to both volumetric and mechanical compression stress.
Implications highlight the need for further study on mechanical environments affecting cancer behavior in vivo.

Implication

Observational analysis shows invasive phenotype and apoptosis resistance in Hep3B cells, suggesting impact of volumetric and mechanical compressions.

Abstract

Regulations of volumetric and mechanical compressions in liver cancer cell line Hep3B.

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Cite This Study

Gong et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd201 https://doi.org/10.1158/0008-5472.29919128

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S10 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
2Figure S12 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
3Figure S13 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
4Figure S2 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
5Figure S6 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025