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August 15, 2025Open Access

Figure S12 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer

Xiangyu Gong Noriyoshi Ogino M. Fátima Leite Dingyao Zhang Zehua Chen Ryan Y. Nguyen Raymond Liu Emma Kruglov Kaitlin M. Flores Aidan T. Cabral Gabriel Moreira de M. Mendes Barbara E. Ehrlich Michael Mak

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Key Points

Volumetric compression induces an invasive phenotype in Hep3B cells, making them more resistant to apoptosis.
The expression and signaling of β-catenin and YAP are altered in Hep3B under volumetric compression, suggesting new pathways involved.
This analysis employs cell culture techniques to examine morphological changes in liver cancer cells subjected to compression.
The findings highlight the need for targeted therapies addressing this apoptosis-resistance in liver cancer treatments.

Implication

This research demonstrates that volumetric compression enhances the invasive phenotype in Hep3B cells, indicating potential treatment challenges.

Abstract

Morphological changes and signaling of β-catenin and YAP in liver cancer cell line Hep3B under volumetric compression.

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Cite This Study

Gong et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd1cf https://doi.org/10.1158/0008-5472.29919179

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S14 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
2Figure S15 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
3Figure S4 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
4Figure S9 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
5Figure S10 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025