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August 15, 2025Open Access

Figure S4 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer

Xiangyu Gong Noriyoshi Ogino M. Fátima Leite Dingyao Zhang Zehua Chen Ryan Y. Nguyen Raymond Liu Emma Kruglov Kaitlin M. Flores Aidan T. Cabral Gabriel Moreira de M. Mendes Barbara E. Ehrlich Michael Mak

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Key Points

The invasive phenotype is driven by apoptosis resistance in liver cancer cells exposed to mechanical compression.
YAP nuclear translocation occurs in HepG2 cells under stress, highlighting a response to volumetric compression.
Observational analysis examines the relationship between mechanical stress and cell behavior in liver cancer models.
These findings suggest that targeting this adaptation may provide new avenues for liver cancer treatment.

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Implication

Analysis reveals YAP nuclear translocation under mechanical compression in HepG2 cells, indicating enhanced invasiveness.

Abstract

YAP nuclear translocation in HepG2 cells under mechanical compression.

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Cite This Study

Gong et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd1c7 https://doi.org/10.1158/0008-5472.29919143

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S12 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
2Figure S16 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
3Figure S15 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
4Figure S9 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
5Figure S13 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025