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August 15, 2025Open Access

Figure S13 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer

Xiangyu Gong Noriyoshi Ogino M. Fátima Leite Dingyao Zhang Zehua Chen Ryan Y. Nguyen Raymond Liu Emma Kruglov Kaitlin M. Flores Aidan T. Cabral Gabriel Moreira de M. Mendes Barbara E. Ehrlich Michael Mak

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Key Points

Mechanical compression leads to a more invasive phenotype in liver cancer cells, affecting their survival and behavior.
Cell morphology changes were distinctly observed between uncompressed and compressed HepG2 cells, indicating strong plasticity.
Daily tracking of HepG2 cells displayed significant differences in response to volumetric compression, revealing adaptability mechanisms.
This research highlights the implications of mechanical factors in tumor behavior, which may inform future liver cancer therapies.

Implication

Observational analysis shows altered cell morphology in HepG2 under compression, suggesting it drives invasive traits.

Abstract

Daily tracking of HepG2-LifeAct cell morphology in the control (no compression applied) and under mechanical compression.

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Cite This Study

Gong et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd128 https://doi.org/10.1158/0008-5472.29919176

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Figure S21 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
2Figure S9 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
3Figure S10 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
4Figure S2 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025
5Figure S15 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer2025