Figure S6 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer

Xiangyu Gong; Noriyoshi Ogino; Maria de Fátima Leite; Dingyao Zhang; Zehua Chen; Ryan Y. Nguyen; Raymond Liu; Emma Kruglov; Kaitlin Flores; Aidan T. Cabral; Gabriel Moreira de M. Mendes; Barbara E. Ehrlich; Michael Mak

doi:10.1158/0008-5472.29919137

August 15, 2025Open Access

Figure S6 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer

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Key Points

Invasive phenotype develops under conditions of volumetric compression, enhancing liver cancer progression.
Key findings indicate that apoptotic resistance is observed as cells experience mechanical compression in 3D.
Assessment of cell protrusive phenotype revealed significant changes in cell-ECM interaction due to compression effects.
These findings highlight potential therapeutic challenges in treating liver cancer linked to mechanical factors.

Implication

Observational analysis identifies invasive phenotype in liver cancer cells under volumetric compression, suggesting implications for treatment strategies.

Abstract

Characterizations of cell protrusive phenotype and cell-ECM interaction in 3D collagen under mechanical compression.

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Cite This Study

Gong et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd18c https://doi.org/10.1158/0008-5472.29919137

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Figure S6 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

Figure S6 from Adaptation to Volumetric Compression Drives an Apoptosis-Resistant and Invasive Phenotype in Liver Cancer

Key Points

Implication

Abstract

Discussion

Cite This Study

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