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August 1, 2025Brain and BehaviorOpen Access

Comprehensive Transcriptomic Analysis of Brain Tissues From the Infarcted Area of MCAO Rats Revealed That Acupuncture Attenuates Brain Injury via the Complement System

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Authors

YLYanlin LiuSouth China Agricultural UniversityYJYuting JinChongqing University of Science and TechnologyYLYuxin LiuFudan University

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Overview

Observational analysis reveals acupuncture reduces brain injury in MCAO rats, suggesting insights into inflammatory pathways.

Key Points

  • Acupuncture significantly downregulates key genes linked to brain injury, indicating a protective effect.
  • A total of 1792 differentially expressed genes were identified between MCAO and acupuncture groups, highlighting therapeutic targets.
  • Analysis included RNA sequencing and complement system assessments, yielding robust data on inflammatory response mechanisms.
  • Findings support acupuncture's role in poststroke recovery and the modulation of inflammatory pathways related to brain injury.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68af5707ad7bf08b1eaddb87https://doi.org/10.1002/brb3.70740
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