Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 20, 2026Open Access

Acupuncture inhibits astrocytic hyperactivation via the p38 mitogen-activated protein kinase/mitogen- and stress-activated protein kinase 1 signaling pathway in cerebral ischemia-reperfusion injury

View Full Paper
Ask AI
Bookmark
Share

Authors

ZZZifeng ZhuangCWChoying WOHCH Chen

Discussion

Loading...

Member takes

Overview

Observational study demonstrates acupuncture reduces astrocyte activation in cerebral ischemia-reperfusion injury, suggesting a therapeutic pathway.

Key Points

  • To investigate how acupuncture affects astrocyte activation through the p38 MAPK/MSK1 signaling pathway after cerebral ischemia-reperfusion injury.
  • Utilized transcriptome and single-cell sequencing to analyze gene expression
  • Conducted experiments on rats subjected to middle cerebral artery occlusion (MCAO)
  • Applied acupuncture as an intervention
  • Assessed astrocyte activation levels post-treatment
  • Acupuncture significantly reduced astrocyte activation in MCAO-induced rats
  • p38 MAPK/MSK1 signaling pathway was inhibited following acupuncture treatment
  • Gene expression profiles indicated reduced inflammatory markers in treated rats

Cite This Study

Zhuang et al. (2026) studied this question.

synapsesocial.com/papers/69e5c2d003c2939914028cabhttps://doi.org/10.19852/j.cnki.jtcm.2026.02.005
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acupuncture Alleviates Cerebral Ischemic Injury via Activating AMPK/SIRT1/PGC-1α Signaling2026
  2. 2Comprehensive Transcriptomic Analysis of Brain Tissues From the Infarcted Area of MCAO Rats Revealed That Acupuncture Attenuates Brain Injury via the Complement System2025
  3. 3Impact of acupuncture on ischemia/reperfusion injury: Unraveling the role of miR-34c-5p and autophagy activation2024 · 6 citations
  4. 4Acupuncture modulates the AMPK/PGC-1 signaling pathway to facilitate mitochondrial biogenesis and neural recovery in ischemic stroke rats2024 · 14 citations
  5. 5Acupuncture Improves Poststroke Cognitive Impairment by Regulating the miR-18a-5p2026