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June 20, 2026Acupuncture & Electro-Therapeutics Research

Acupuncture Alleviates Cerebral Ischemic Injury via Activating AMPK/SIRT1/PGC-1α Signaling

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Authors

PHPanfu HaoSWS WangSCSifang Chen

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Overview

Randomized trial demonstrates acupuncture alleviates cerebral ischemic injury in rats, indicating potential therapeutic benefits.

Key Points

  • This study aims to explore the effects of acupuncture on cerebral ischemic stroke injury.
  • Middle cerebral artery occlusion (MCAO) surgery established a cerebral ischemic injury rat model.
  • mRNA levels were analyzed by reverse transcription-quantitative polymerase chain reaction (RT-qPCR).
  • Protein and cytokine levels were determined by Western blot and enzyme-linked immunosorbent assay (ELISA), respectively.
  • Acu treatment alleviated neurologic deficits after ischemic injury.
  • Acu treatment reduced the release of proinflammatory cytokines, including interleukin 6.
  • Acu treatment activated AMPK/SIRT1/PGC-1α signaling, inhibiting neuronal death and improving mitochondrial functions.

Cite This Study

Hao et al. (2026) studied this question.

synapsesocial.com/papers/6a362fbcdb0793dc1a53725bhttps://doi.org/10.1177/03601293261459144
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