Figure 3 from Plasma Proteomic Analysis Reveals Complement System Changes in Irradiated Female BALB/c Mice during Mammary Carcinogenesis

Network analysis of differentially expressed proteins in irradiated mice. A–C, Volcano plot of differentially expressed proteins in tumor-free mice from the IR group compared with controls at (A) 4 months, (B) 8 months, and (C) 18 months. D, Network analysis highlights the complement system as a predominant pathway. E, Pathway enrichment of complement systems indicated by gene ontology, components, and WIKI Pathways. Each colored circle in the table represents the placement of a protein within the network. Proteins that occur in multiple colors in the network indicate their simultaneous involvement in multiple highlighted pathways.