Comparative Insights into Polymers for Solid Dispersions: Mechanisms, Sustainability, Regulatory and Clinical Perspectives

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Discussion

Review highlights mechanisms and bioavailability in solid dispersion systems, suggesting avenues for sustainable polymers.

Bioavailability significantly improves in poorly soluble drugs using solid dispersion methods, emphasizing polymer importance.
Polymers are essential in solid dispersions, with clinical cases showing successful drug delivery in approved products.
The review analyzes various polymers' physicochemical properties and their roles in drug formulation and compatibility.
Future developments focus on more sustainable and biodegradable polymers, aligning with global regulatory goals.

Umekar et al. (2025) studied this question.

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