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March 25, 2026Open Access

Impact of Hydrophilic Polymers on the Physicochemical Properties and Dissolution Behaviour of BCS Class II Drug Solid Dispersions

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Authors

RSRahul SoroutDKDr. Mukesh Kumar

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Overview

Conceptual analysis explores how hydrophilic polymers enhance dissolution in BCS Class II drugs, suggesting improved formulation strategies.

Key Points

  • This research aims to evaluate the effects of hydrophilic polymers on the dissolution behavior of BCS Class II drugs, using Eprosartan as a model compound.
  • Analyzed the interactions between various hydrophilic polymers and Eprosartan in solid dispersions.
  • Investigated physicochemical properties such as wettability and thermal performance.
  • Assessed the impact of different polymer types on drug dissolution rates and stability.
  • Hydrophilic polymers significantly enhance the dissolution rate and stability of Eprosartan.
  • Specific polymers showed different effects on the physicochemical properties and crystallinity of solid dispersions.
  • The choice of polymer is crucial for achieving optimal dissolution and stability outcomes.

Cite This Study

Sorout et al. (2026) studied this question.

synapsesocial.com/papers/69c37b62b34aaaeb1a67dcbfhttps://doi.org/10.5281/zenodo.19184011
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