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This is a In Vitro Study study.

August 22, 2025

A Novel Photocatalytic Ring Opening Reaction of Silacyclobutanes with Alkenes

Key Points

The photocatalytic method yields silanols efficiently from silacyclobutanes and alkenes, demonstrating successful reaction conditions.
Utilizing hexafluoroisopropanol as a promoter, the reaction accommodates a variety of active alkenes effectively.
A range of challenging silanols with a tetraorganosilicon stereocenter can be synthesized through this approach with good yields.
This strategy extends to include reactions with ethynylbenziodoxolone, showcasing its versatility in organic synthesis.

Abstract

Comprehensive Summary Herein, we wish to report a novel photocatalytic ring opening reaction of silacyclobutanes (SCBs) with alkenes using hexafluoroisopropanol (HFIP) as the promoter. The protocol is mild and green, and is capable of accommodating a wide range of active alkenes, allowing for the facile synthesis of challenging silanols with a tetraorganosilicon stereocenter in good yields in combination with the following hydrolysis. Notably, this strategy could be extended to the reaction with ethynylbenziodoxolone.

A Novel Photocatalytic Ring Opening Reaction of Silacyclobutanes with Alkenes

Key Points

Abstract

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