Case report highlights development of sialorrhea in a patient with recurrent depression on lithium, suggesting careful monitoring is needed.
Medications for bipolar affective disorder and unipolar depression frequently involve the use of lithium, a mood stabilizer. Because of its limited therapeutic window, regular monitoring of serum lithium levels and clinical assessment is crucial. Sialorrhea, terminology used for hypersalivation or excessive drooling, is a common complication of many psychotropic medications but has rarely been noticed as a side effect in patients on oral lithium therapy. Here, we present a case of recurrent depressive disorder that developed sialorrhea after 6 months of taking lithium at a subtherapeutic level.
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Shafiq et al. (2025) studied this question.
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