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Case of lithium overdose reveals risks from NSAIDs and infection in an adult male, highlighting urgency for treatment.
Lithium is a medication mainly used to treated bipolar disorder.Lithium can have many drugs interaction including thiazide diuretics, non-steroidal anti-inflammatory drugs (NSAIDS) and selective serotonin reuptake inhibitors (SSRIs) leading to decreased lithium clearance.Supratherapeutic levels can cause toxicity and manifest as neurological symptoms.High clinical suspicion is required for prompt treatment to avoid long term sequela and even death.This is a case of a 57 year old male presented with ataxia, dysarthria with poor oral intake and laboratories remarkable for supratherapeutic lithium levels; an aftermath of NSAIDs use in which a parallel infectious process lead to volume depletion and renal failure causing acute lithium toxicity.
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Morell-Castro et al. (2026) studied this question.
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