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July 6, 2026Revista de Educación en Cuidados Críticos (REduCrític)Open Access

The perfect cycle for a lithium overdose

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Authors

MMMarta M. Morell-CastroSRStephanie Rivera-RiveraIVIlia Velez-Rodriguez

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Overview

Case of lithium overdose reveals risks from NSAIDs and infection in an adult male, highlighting urgency for treatment.

Key Points

  • This case aims to illustrate the clinical presentation and risks associated with lithium overdose due to drug interactions.
  • Presented a case of a 57-year-old male with neurological symptoms and elevated lithium levels.
  • Investigated the role of NSAID use and its impact on lithium clearance and renal function.
  • Emphasized the need for prompt treatment to prevent complications.
  • Patient exhibited ataxia and dysarthria linked to high lithium levels (supratherapeutic).
  • Renal failure and volume depletion were attributed to NSAID use and an infectious process.
  • Prompt clinical intervention was critical to prevent long-term complications.

Cite This Study

Morell-Castro et al. (2026) studied this question.

synapsesocial.com/papers/6a4b44fa997070ff83b5afdchttps://doi.org/10.24875/recc.25000013
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lithium Toxicity or Alcohol Withdrawal?2026 · 1 citations
  2. 2LITHIUM AND NSAIDS: LIFE THREATENING TOXICITY OF LITHIUM PRECIPITATED BY A COMMON OVER THE COUNTER MEDICATION2024
  3. 3Syndrome of Irreversible Lithium-Effectuated Neurotoxicity: Silent, but not innocent2024 · 1 citations
  4. 4Severe Lithium Toxicity Following Concurrent Lithium and Nabumetone Use in a Patient With Bipolar I Disorder: A Case Report2026
  5. 5The Syndrome of Irreversible Lithium-Effectuated Neurotoxicity: A Report of Two Cases2025