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June 17, 2026CureusOpen Access

Lithium Toxicity or Alcohol Withdrawal?

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Authors

TNTanya NagpalTBTaylore BakerAFAudrey S Farooqui

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Overview

Case analysis reveals lithium toxicity symptoms despite low serum levels in a patient with alcohol withdrawal.

Key Points

  • To assess the clinical manifestations and management of lithium toxicity in a patient post-acute overdose amid alcohol withdrawal.
  • Described case of a 43-year-old male with bipolar I disorder and history of alcohol use admitted for lithium overdose.
  • Initial treatment included medications for alcohol withdrawal and intravenous fluids, followed by hemodialysis due to neurologic decline.
  • Monitoring involved tracking serum lithium levels and clinical symptoms throughout treatment.
  • Patient exhibited neurological decline with subtherapeutic serum lithium levels.
  • Following three rounds of hemodialysis, patient returned to normal neurologic baseline.
  • Significant disparity noticed between symptom severity and serum lithium levels, emphasizing toxicity risk.

Cite This Study

Nagpal et al. (2026) studied this question.

synapsesocial.com/papers/6a323957d50b63ecad204dddhttps://doi.org/10.7759/cureus.110838
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Understanding Lithium intoxication in Bipolar Disorder: a comparative analysis and clinical implications2024
  2. 2The perfect cycle for a lithium overdose2026
  3. 3Unintentional Lithium Toxicity in Patients With Bipolar Disorder2026
  4. 4Lithium withdrawal and relapse in bipolar disorder when kidney function deteriorates2024 · 1 citations
  5. 5Indications for Dialysis in Lithium Toxicity: A Narrative Review2026