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August 13, 2026Journal of Clinical Psychopharmacology

Unintentional Lithium Toxicity in Patients With Bipolar Disorder

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Authors

LSLuana Almeida de Souza SilvaLALuciana de Andrade Agostinho

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Overview

Literature review synthesizes case reports of lithium toxicity in bipolar disorder, indicating significant clinical complications.

Key Points

  • This review aims to highlight the occurrence and implications of unintentional lithium toxicity in bipolar disorder patients.
  • Identified case reports from PubMed and Virtual Health Library (2009-2024) using keywords: lithium, intoxication, bipolar disorder.
  • Included adult patients with unintentional lithium toxicity, extracting data on demographics, clinical presentations, and lab results.
  • Conducted descriptive analysis on clinical manifestations and serum lithium concentrations.
  • Included 21 case reports with 76.2% female patients, mean age of 61 years.
  • Neurological symptoms were common, with tremor (61.9%) and altered mental status (42.9%) being prevalent.
  • 81.0% of cases had serum lithium concentrations >1.5 mmol/L, with significant cases occurring at therapeutic levels.

Cite This Study

Silva et al. (2026) studied this question.

synapsesocial.com/papers/6a7d76e62b0e0cff3f640b09https://doi.org/10.1097/jcp.0000000000002236
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Understanding Lithium intoxication in Bipolar Disorder: a comparative analysis and clinical implications2024
  2. 2Lithium nephropathy in Bipolar Disorder: a clinical challenge2024 · 1 citations
  3. 3Syndrome of Irreversible Lithium-Effectuated Neurotoxicity: Silent, but not innocent2024 · 1 citations
  4. 4Effects of Erratic Lithium Usage: Sinus Bradycardia and Hyperpigmentation2026
  5. 5Chronic Lithium‐Induced Cardiotoxicity: A Case Report and Lessons for Clinical Practice2025 · 6 citations