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July 8, 2026CureusOpen Access

Severe Lithium Toxicity Following Concurrent Lithium and Nabumetone Use in a Patient With Bipolar I Disorder: A Case Report

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Authors

MHMichael R HowerHAHolly AgudPPPrasad R. Padala

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Overview

Case report reveals severe lithium toxicity in a patient with bipolar I disorder after dosage escalation of lithium and nabumetone, highlighting drug interactions.

Key Points

  • This report aims to discuss severe lithium toxicity resulting from concurrent use of lithium and nabumetone in bipolar I disorder.
  • Case report of a 50-year-old woman with bipolar I disorder on chronic lithium therapy.
  • Monitoring of serum lithium concentrations and administration of intravenous fluids after drug discontinuation.
  • Assessment using the Naranjo Adverse Drug Reaction Probability Scale.
  • Patient developed severe lithium toxicity with a serum concentration over 2.9 mmol/L.
  • Neurocognitive symptoms improved rapidly after discontinuation of lithium and nabumetone.
  • Lithium was safely reintroduced at a reduced dose without recurrence of toxicity.

Cite This Study

Hower et al. (2026) studied this question.

synapsesocial.com/papers/6a4de9e4d2ea289ef6283d07https://doi.org/10.7759/cureus.112142
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Also Consider

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  4. 47320 A Case Of Concurrent Lithium-Associated Hyperthyroidism, Nephrogenic Diabetes Insipidus, Primary Hyperparathyroidism, And Acute Pancreatitis2024
  5. 5Effects of Erratic Lithium Usage: Sinus Bradycardia and Hyperpigmentation2026