Pd(II) catalyzes decarboxylation-alkylation of 3-formylindoles with nitroalkenes, suggesting new indole derivatives.
We present herein a Pd(II)‐catalyzed oxidative decarboxylation reaction of 3‐formylindoles with nitroalkenes to construct various 3‐(2‐nitroalkyl)indoles, which can be used to prepare tryptamines and related indole‐containing bioactive compounds. The reaction features broad substrate scope and high regioselectivity. Mechanistic studies were carried out to shed insights into the reaction mechanism.
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Wang et al. (2025) studied this question.
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