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August 24, 2025International Journal of Molecular SciencesOpen Access

Molecular Mechanisms of Phthalates in Depression: An Analysis Based on Network Toxicology and Molecular Docking

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Authors

RZRuiqiu ZhangHWHairuo WenZLZhi Lin

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Overview

Analysis shows phthalates affect depression-related target genes, indicating environmental pollution risks.

Key Points

  • Comparative analysis identified 360 common targets between phthalates and depression, underscoring their connection.
  • Molecular docking revealed strong binding activity of phthalates with target genes like CASP3 and TNF, indicating risk mechanisms.
  • Analysis utilized network toxicology to construct a Protein-Protein Interaction network and screen for key hub genes.
  • Findings suggest phthalates are involved in depression through several biological pathways, highlighting health risk relevance.

Cite This Study

Zhang et al. (2025) studied this question.

synapsesocial.com/papers/68af5bc7ad7bf08b1eadffd9https://doi.org/10.3390/ijms26178215
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Unveiling Molecular Mechanisms and Salient Targets in Phthalates‐Induced Neurodevelopmental Disorders Through Comprehensive Network Toxicology and Molecular Docking Strategy2026 · 1 citations
  2. 2Exploring the molecular mechanisms of phthalates in the comorbidity of preeclampsia and depression by integrating multiple datasets2025
  3. 3Exploring the phthalates-induced neurotoxicity mechanisms of neurodegenerative diseases via network toxicology, single-cell transcriptomics and molecular dynamic simulation2026 · 3 citations
  4. 4Bisphenol a exposure and major depressive disorder: an integrative analysis combining network toxicology, molecular docking, genetic epidemiology, and transcriptomic validation2026
  5. 5Association of Exposure to Phthalate Metabolites with Antenatal Depression in US Pregnant Women2025