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August 25, 2025Future Journal of Pharmaceutical SciencesOpen Access

Neuroprotective effects of Artemisia monosperma against LPS-induced neuroinflammation via TLR4 modulation and myeloperoxidase inhibition: metabolomic and molecular insights

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Authors

MDMarwa Samir M. DoniaABAhmed M. BadawyNQNehal Qwaider

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Overview

Analysis shows neuroprotective potential and modulates TLR4 in Neuro 2a cells, suggesting new therapies for neuroinflammatory disorders.

Key Points

  • Artemisia monosperma significantly reduces neuroinflammation and oxidative stress in Neuro 2a cells, improving neuroprotection.
  • The extract shows antioxidant capacities with total phenolic and flavonoid contents of 73.85 μg GA E/mg and 22.38 µg RE/mg, respectively.
  • Analysis used LC-ESI-TOF–MS/MS to identify 48 polyphenolic compounds, highlighting the metabolomic profile and effectiveness.
  • The study reveals potential for Artemisia monosperma in treating neurodegenerative conditions by inhibiting TLR4 and myeloperoxidase.

Cite This Study

Donia et al. (2025) studied this question.

synapsesocial.com/papers/68af5d63ad7bf08b1eae08c1https://doi.org/10.1186/s43094-025-00870-y
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  1. 1Emodin Attenuates Lipopolysaccharide-Induced Acute Liver Injury via Inhibiting the TLR4 Signaling Pathway in vitro and in vivo2018 · 80 citations
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  4. 4Phenolic Diversity and Antioxidant Activity of Artemisia abrotanum L. and Artemisia absinthium L. during Vegetation Stages2023 · 16 citations