The Synchrony of STARD4‐AS1 and H19 Downregulation with Cardiomyocytes Cell Cycle Arrest

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In vitro analysis shows downregulation of lncRNAs STARD4-AS1 and H19 in cardiomyocytes, indicating potential targets for cardiac regeneration.

Downregulation of STARD4-AS1 and H19 lncRNAs leads to persistent cell cycle arrest in cardiomyocytes after birth, impacting regeneration.
Importantly, human embryonic stem cell-derived cardiomyocytes showed permanent downregulation of these lncRNAs across multiple timepoints.
Analysis of public transcriptomic datasets revealed critical insights into lncRNA expression patterns in cardiomyocytes.
This research suggests targeting STARD4-AS1 and H19 may enhance cardiac regenerative therapies, addressing underlying injuries.

Shiri et al. (2025) studied this question.

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In vitro analysis shows downregulation of lncRNAs STARD4-AS1 and H19 in cardiomyocytes, indicating potential targets for cardiac regeneration.