August 2, 2017Nature CommunicationsOpen Access

Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo

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Population

Cardiomyocytes from mouse and human failing and non-failing adult hearts

Design

Preclinical

Authors

KSKelvin SeeNational University of Singapore WTWilson Lek Wen TanAgency for Science, Technology and Research ELEng How LimNational University Health System

Discussion

Member takes

Implication

Heterogeneity in cardiomyocyte stress responses may guide future regeneration strategies; leaves open whether specific subpopulations can be therapeutically targeted.

Structured PICO

Population

Cardiomyocytes from mouse and human failing and non-failing adult hearts

Intervention

Knockdown of nodal long intergenic non-coding RNAs (lincRNAs)

Outcome

Expression levels of genes related to dedifferentiation and cell cyclesurrogate

Identification of lincRNA-regulated dedifferentiation and cell cycle stress-responses suggests sub-populations of adult cardiomyocytes possess endogenous potential for cardiac regeneration.

Cite This Study

See et al. (2017) studied this question.

synapsesocial.com/papers/6a6fdab3f44fa9f079dd58f2 https://doi.org/10.1038/s41467-017-00319-8

Topics

Heart failure HFrEF treatment

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Implication

Heterogeneity in cardiomyocyte stress responses may guide future regeneration strategies; leaves open whether specific subpopulations can be therapeutically targeted.

Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider