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August 25, 2025Clinical Medicine And Health Research JournalOpen Access

The Key to Combating Sickle Cell Disease in High-Prevalence Regions Like Mali: Hemoglobin Electrophoresis for All, From Birth to Marriage

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Authors

VKVeli KarabugaMali-FolkecenterMDM DiarraUniversity of BamakoDCDrissa CoulibalyUniversity of Bamako

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Overview

Observational analysis identified a carrier prevalence of 15.6% in children, suggesting hemoglobin electrophoresis can aid SCD prevention in Mali.

Key Points

  • Sickle cell trait prevalence was found to be 15.6% among children tested, indicating higher rates than previously estimated.
  • Significantly lower hemoglobin levels were observed in patients with the homozygous form (Hb SS), averaging 8.33 g/dL.
  • This analysis utilized hemoglobin data from 1,737 children to evaluate the SCD situation in Mali, enhancing screening awareness.
  • Importance of hemoglobin electrophoresis is underscored, as it is crucial for distinguishing carriers from non-carriers for SCD.

Cite This Study

Karabuga et al. (2025) studied this question.

synapsesocial.com/papers/68af5f0dad7bf08b1eae1b3ahttps://doi.org/10.18535/cmhrj.v5i04.502
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Systematic point‐of‐care newborn screening for sickle cell disease in rural Mali, West Africa2025 · 3 citations
  2. 2Point-of-Care Newborn Screening for Sickle Cell Disease at Selected Health Facilities in the Gambia2024 · 8 citations
  3. 3Strengthening Newborn Screening: A Pilot Health Program Management for Sickle Cell Disease in Côte d’Ivoire2026
  4. 4Hemoglobin status in children attending paediatric clinics in Lomé, 2022.2024
  5. 5Burden of sickle cell anemia in Africa: A systematic review and meta-analysis2025 · 6 citations