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July 1, 2025Research in Pharmaceutical SciencesOpen Access

Development and evaluation of gelatin/hyaluronic acid nanofibrous dressing loaded with silver nanoparticles and phenytoin for enhanced wound healing: an in-vitro and in-vivo study

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Authors

JEJaber EmamiIsfahan University of Medical SciencesNMNiloofar MostolizadehIsfahan University of Medical SciencesMTMajid TabbakhianIsfahan University of Medical Sciences

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Overview

Experimental study shows enhanced wound healing in chronic wounds with gelatin-hyaluronic acid nanofibers, suggesting potential for clinical application.

Key Points

  • Significantly faster wound healing observed in in vivo experiments, with complete healing in 15 days.
  • Nanofibers loaded with Ag NPs and phenytoin exhibited high swelling (822.2%) and drug loading efficiencies of 56% and 61%.
  • Electrospun gelatin-hyaluronic acid nanofibers were fabricated, showing strong antibacterial activity in vitro.
  • Promising advanced wound dressings could lower healthcare costs associated with chronic wound management.

Cite This Study

Emami et al. (2025) studied this question.

synapsesocial.com/papers/68af5f1ead7bf08b1eae24ebhttps://doi.org/10.4103/rps.rps_60_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antimicrobial Silver Nanoparticles for Wound Healing Application: Progress and Future Trends2019 · 544 citations
  2. 2Synthesis, Characterization and Biomedical Application of Silver Nanoparticles2022 · 339 citations
  3. 3Gelatin/hyaluronic acid nanofibrous scaffolds: biomimetics of extracellular matrix2013 · 16 citations
  4. 4Polyurethane infused with heparin capped silver nanoparticles dressing for wound healing application: Synthesis, characterization and antimicrobial studies2024 · 15 citations
  5. 5Growth Kinetic Study of Tannic Acid Mediated Monodispersed Silver Nanoparticles Synthesized by Chemical Reduction Method and Its Characterization2021 · 68 citations