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August 26, 2025Open Access

Liposome integrated hydrogel for diabetic wound healing: Molecular mechanisms in inflammation and oxidative stress mitigation

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Authors

DMDyandevi MathureSavitribai Phule Pune UniversityPDP. S. DeshmukhShivaji UniversityMSMalati SalunkeBharati Vidyapeeth Deemed University

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Overview

Observational analysis shows over 98% wound closure in diabetic models using a liposome-integrated hydrogel, suggesting its potential in healing therapies.

Key Points

  • Liposomal hydrogel achieved over 98% wound closure in diabetic and nondiabetic rats, demonstrating its effectiveness.
  • The optimized liposomes, with particle size of 184.5nm and entrapment efficiency of 91%, aid in drug delivery.
  • Assessment using factorial design for liposome preparation led to superior permeation of 73.41% compared to plain gel.
  • This formulation highlights a promising drug delivery method for enhancing wound healing outcomes in diabetes.

Cite This Study

Mathure et al. (2025) studied this question.

synapsesocial.com/papers/68af6203ad7bf08b1eae2b37https://doi.org/10.21203/rs.3.rs-7286961/v1
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