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March 1, 2026

Potential Therapeutic Benefits of Lutein-loaded Hydrogel in Diabetic-Induced Dermal Wound Healing.

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Authors

ZRZuha RahmanVAVidhu Aeri

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Overview

In vitro and in vivo studies explore lutein-loaded hydrogels effective in wound healing for diabetic models, suggesting new treatment approaches.

Key Points

  • To evaluate the wound-healing efficacy of lutein-loaded hydrogel in diabetic-induced wounds.
  • Conducted in silico docking studies to assess lutein's interactions with wound-related proteins.
  • Formulated and tested hydrogel formulations for physicochemical stability and drug delivery efficiency.
  • Performed in vitro and ex vivo studies to compare skin permeation and drug release of lutein-loaded hydrogels.
  • Utilized diabetic rat models to evaluate in vivo effects on wound healing and tissue regeneration.
  • Achieved 92.1% wound closure by day 9 and complete healing by day 11 in diabetic rats.
  • Histopathological analysis showed dense granulation tissue and minimal inflammation in treated wounds.
  • Lutein-loaded hydrogel demonstrated superior skin permeation and sustained drug release compared to controls.

Cite This Study

Rahman et al. (2026) studied this question.

synapsesocial.com/papers/69a3d7dfec16d51705d2e4bchttps://doi.org/10.1080/1061186x.2026.2639022
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Also Consider

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  2. 2A Multifunctional Hydrogel Incorporating Luteolin-Encapsulated ROS-Responsive Nanoparticles and Stem Cells Promotes Bacterial-Infected Wound Healing2026 · 1 citations
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  4. 4Multi‐Modal Therapy for Diabetic Ulcers: A Hydrogel Platform Combining Antibacterial, Oxygenating, ROS‐Scavenging, and Pro‐Healing Functions2025
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