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August 25, 2025Italian Journal of MedicineOpen Access

SERAFINO MANSUETO AWARD | The prognostic value of Mid-Regional-pro-adrenomedullin serum levels in predicting in-hospital death in patients with sepsis and septic shock

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Overview

Prospective study reveals mid-regional-pro-adrenomedullin levels predict in-hospital mortality in sepsis, indicating its clinical significance.

Key Points

  • Higher mid-regional-pro-adrenomedullin levels (5.69 nmol/L) significantly predict in-hospital mortality in patients with sepsis.
  • ROC analysis shows a cutoff value of 3 nmol/L for mid-regional-pro-adrenomedullin with an AUC of 0.873, indicating strong predictive ability.
  • 41 patients, majority male (76%), were studied to assess the impact of mid-regional-pro-adrenomedullin levels on mortality outcomes.
  • Baseline mid-regional-pro-adrenomedullin greater than 3 nmol/L independently increases the risk of in-hospital death by 3.75 times.

Cite This Study

A 2025 study studied this question.

synapsesocial.com/papers/68af6216ad7bf08b1eae3678https://doi.org/10.4081/itjm.2025.2149
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