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December 13, 2023International Journal of Molecular SciencesOpen Access

Mid-Regional Pro-Adrenomedullin Can Predict Organ Failure and Prognosis in Sepsis?

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Why the study?

To determine an MR-proADM value that identifies patients with localized infection, sepsis or septic shock, specific organ damage, need for ICU transfer, and prognosis, and to correlate it with length of stay.

Does mid-regional pro-adrenomedullin (MR-proADM) predict organ failure and prognosis in patients with sepsis or localized infection?

Population

301 subjects with sepsis (124/301 with septic shock) and 126 with localized infection

Comparison

MR-proADM levels across clinical severities, organ failures, and outcomes

Design

Retrospective study

Authors

SSSilvia SpotoSBStefania BasiliRCRoberto Cangemi

Discussion

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Member takes

Overview

MR-proADM cutoffs may aid sepsis severity assessment; leaves open prospective validation before guiding ICU decisions.

Structured PICO

Does mid-regional pro-adrenomedullin (MR-proADM) predict organ failure and prognosis in patients with sepsis or localized infection?

P
Population
427 retrospectively included subjects, comprising 301 with sepsis (124 with septic shock) and 126 with localized infection.
I
Intervention
Mid-regional pro-adrenomedullin (MR-proADM) measurement
O
Outcome
Identification of patients with localized infection or sepsis/septic shock, specific organ damage, need for intensive care unit (ICU) transfer, and prognosissurrogate

MR-proADM is a valuable biomarker that reflects oxidative stress and correlates proportionally with organ damage severity, ICU admission need, and mortality in sepsis.

Cite This Study

Spoto et al. (2023) studied this question.

synapsesocial.com/papers/6a7e47a2c75b6bdf92b7add9https://doi.org/10.3390/ijms242417429
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