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July 11, 2026Journal of Anesthesia Analgesia and Critical CareOpen Access

Prognostic value and organ-specific correlations of admission MR-proADM in critically ill patients: a retrospective exploratory study

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Authors

RDRoberta DomiziEDElisa DamianiACAndrea Carsetti

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Overview

Retrospective exploratory study finds MR-proADM correlates with organ failure in critically ill patients, suggesting potential clinical utility.

Key Points

  • This study investigates mid-regional pro-adrenomedullin (MR-proADM) as an early indicator of organ failure in critically ill patients.
  • Retrospective, single-center study involving 26 critically ill patients.
  • Plasma MR-proADM levels assessed at admission and daily for 5 days.
  • Correlations between admission MR-proADM and the 24-h SOFA score were primarily analyzed.
  • Admission MR-proADM showed a moderate correlation with the 24-h SOFA score (rho = 0.488; p = 0.021).
  • In septic patients, MR-proADM levels were significantly higher than non-septic patients (10.90 vs. 1.30 nmol/L, p < 0.001).
  • Higher MR-proADM values were noted in non-survivors compared to survivors, indicating a potential link to mortality, albeit preliminarily.

Cite This Study

Domizi et al. (2026) studied this question.

synapsesocial.com/papers/6a51de38c18d7f28ca50037fhttps://doi.org/10.1186/s44158-026-00428-1
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