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May 20, 2026International Journal of Critical Illness and Injury ScienceOpen Access

Prognostic accuracy of mid-regional proadrenomedullin in patients with sepsis – A longitudinal observational study

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Authors

AMAkshita MakkarHKH. L. KhushbooMBMukesh Bairwa

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Overview

Longitudinal observational study finds mid-regional proadrenomedullin predicts mortality in sepsis, suggesting improved risk assessment.

Key Points

  • This study aims to evaluate the prognostic accuracy of mid-regional proadrenomedullin in predicting mortality among patients with sepsis.
  • Prospective observational study conducted over 18 months at a tertiary hospital in North India
  • Included 120 patients with sepsis in ICU and ward, measuring serum MR-proADM, PCT, and lactate
  • Calculated SOFA and APACHE II scores and assessed prognostic accuracy through ROC analysis.
  • Mean age of participants was 45.9 years, with nonsurvivors requiring more ICU care (69.6%)
  • MR-proADM levels were significantly higher in nonsurvivors (2.48 nmol/L) than survivors (1.43 nmol/L, P < 0.001)
  • MR-proADM achieved an ROC area of 0.767, surpassing PCT (0.693) and APACHE II (0.699) but lower than lactate (0.807).

Cite This Study

Makkar et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fd2f03e14405aa9b54ehttps://doi.org/10.4103/ijciis.ijciis_142_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1SERAFINO MANSUETO AWARD | The prognostic value of Mid-Regional-pro-adrenomedullin serum levels in predicting in-hospital death in patients with sepsis and septic shock2025
  2. 2Mid-Regional Pro-Adrenomedullin (MR-proADM) as a Biomarker for Sepsis and Septic Shock: Narrative Review2018 · 75 citations
  3. 3Prognostic value and organ-specific correlations of admission MR-proADM in critically ill patients: a retrospective exploratory study2026
  4. 4Mid-regional pro-adrenomedullin predicts poor outcome in non-selected patients admitted to an intensive care unit2018 · 31 citations
  5. 5Mid-Regional Pro-Adrenomedullin Can Predict Organ Failure and Prognosis in Sepsis?2023 · 9 citations