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August 26, 2025ACS OmegaOpen Access

Membrane-Modifying Effects of Perfluoroalkyl Substances in Model Bacterial Membranes

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Authors

MPMicaela PanellaARAmani RabadiJCJasmin Ceja-Vega

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Overview

Study reveals PFAS salts disrupt lipid packing and increase permeability in bacterial membranes, indicating ecological impacts.

Key Points

  • PFAS exposure significantly increases membrane permeability, especially in membranes with higher curvature stress.
  • PFOA and PFBS induce concentration-dependent disordering in DOPC/DOPG and DOPE/DOPG membrane mixtures.
  • Differential scanning calorimetry indicates more destabilization in DOPE-DOPG mixtures compared to DOPC-DOPG membranes.
  • Interactions between electrostatic forces and hydrogen bonds are critical in determining the effects of PFAS on membranes.

Cite This Study

Panella et al. (2025) studied this question.

synapsesocial.com/papers/68af63ddad7bf08b1eae3fafhttps://doi.org/10.1021/acsomega.5c04177
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Also Consider

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