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October 17, 2025Open Access

Synthesis of perfluorooctanoic acid-containing membrane lipids by human pathobionts

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Authors

ZGZiqiang GuanUniversity of New HampshireAUAparna UppuluriThe University of Texas at DallasCGChen GuanQingdao University

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Overview

Lipidomic analysis unveils unique fluoroalkyl lipids synthesized by Enterococcus faecalis and Pseudomonas aeruginosa, suggesting novel implications for PFAS interaction.

Key Points

  • Both Enterococcus faecalis and Pseudomonas aeruginosa synthesized unique fluoroalkyl-containing lipids upon exposure to PFOA.
  • A high-level daptomycin-resistant strain of E. faecalis produced significantly higher amounts of fluoroalkyl lipids than non-resistant strains.
  • Lipidomic analyses utilized liquid chromatography-tandem mass spectrometry (LC-MS/MS) to uncover the lipid remodeling mechanisms in bacteria exposed to PFOA.
  • PFAS-containing bacterial lipids may act as novel mediators influencing host-microbe interactions and pollutant dynamics.

Cite This Study

Guan et al. (2025) studied this question.

synapsesocial.com/papers/68f199c5de32064e504dcef6https://doi.org/10.1101/2025.10.14.682380
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1BPS2026 – Interaction of perfluoroalkyl substances with lipid membranes2026
  2. 2Legacy and alternative per- and polyfluoroalkyl substances (PFAS) alter the lipid profile of HepaRG cells2024 · 39 citations
  3. 3Membrane-Modifying Effects of Perfluoroalkyl Substances in Model Bacterial Membranes2025 · 8 citations
  4. 4Gut microbiome-mediated mechanisms of per- and polyfluoroalkyl substances (PFAS) biotransformation and their implications for human health2026
  5. 5A Review on Environmental Occurrence and Toxicity of Perfluorooctanoic Acid and Its Selected Short-Chain Analogs—Perfluorohexanoic Acid and Perfluorobutanoic Acid2026