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January 1, 2025RSC AdvancesOpen Access

Cu/ZnO@GO promoted green synthesis of novel dipyridopyrimidines: evaluation of biological activity and theoretical study of the mechanism using a DFT method

Elham Ezzatzadeh Nasrin Karami Hezarcheshmeh Reza Akbari

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Key Points

The green synthesis of dipyridopyrimidines displays significant biological activity, showcasing potential applications in pharmaceuticals.
Using small quantities of Cu/ZnO@GO nanocatalyst, the method enabled a viable multicomponent reaction environment.
Conducted at room temperature, the process incorporated acetylacetone, aldehydes, and guanidine in a simple setup.
The theoretical study employed DFT methods to elucidate the reaction mechanism, supporting its feasibility and efficiency.

Implication

Multicomponent reaction generates dipyridopyrimidines with notable biological activity, highlighting green synthesis using Cu/ZnO@GO.

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Cite This Study

Ezzatzadeh et al. (2025) studied this question.

synapsesocial.com/papers/68af63e3ad7bf08b1eae4437 https://doi.org/10.1039/d5ra04054j

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