Green Synthesis of Novel Cyclopenta[1,2‐d]pyrimidins Using Ag/Fe₃O₄@GO Nanocatalyst: Characterization and Biological Activity

In this research, novel derivatives of cyclopenta[1,2‐d]pyrimidin with a high level of efficiency were synthesized using Ag/Fe 3 O 4 @Graphene oxide (Ag/Fe 3 O 4 @GO) employing multicomponent reaction including vinylidenes, aldehydes, ethyl 2‐amino‐4‐dioxo‐4‐arylbutanoates, alkyl bromides, and guanidine in water at room temperature. The produced compounds exhibit antioxidant activity as a result of the evaluation processes conducted on their NH group. Furthermore, an evaluation was performed on the antibacterial effectiveness of newly created pyridines using a disk diffusion technique, utilizing two different strains of Gram‐negative bacteria. Significantly, the substances that were evaluated showed inhibitory effects on the development of Gram‐positive bacteria as well. This method has several benefits, including quick response times, high product yields, and easy separation of catalyst and product using simple procedures.