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August 25, 2025Veterinary SciencesOpen Access

Construction and Characterization of a Vesicular Stomatitis Virus Chimera Expressing Schmallenberg Virus Glycoproteins

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Authors

HGHuijuan GuoZJZ. JiangJWJing Wang

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Overview

This research demonstrates a recombinant virus for neutralizing antibody testing in ruminants, indicating its potential in serological screening and vaccine evaluation.

Key Points

  • The recombinant virus exhibits SBV-specific cell tropism, providing a new avenue for serological testing.
  • Characterization confirmed effective glycoprotein expression and viable growth kinetics of the chimera.
  • Reverse genetics techniques were utilized to create the recombinant strain, addressing challenges of non-endemic regions.
  • This approach may improve the measurement of neutralizing antibodies against the Schmallenberg virus, suggesting broader applications in vaccine efficacy studies.

Cite This Study

Guo et al. (2025) studied this question.

synapsesocial.com/papers/68af63e9ad7bf08b1eae48c1https://doi.org/10.3390/vetsci12090809
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