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September 5, 2025Open Access

Age-related changes in behavioral and neural variability in a decision-making task

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Older mice exhibit increased variability of response times during decision-making tasks, indicating cognitive decline.
Firing rates were generally higher in older mice, with a notable distinction across various brain regions.
Post-stimulus neural variability was analyzed using the Fano Factor, showcasing age-related differences.
Findings highlight that ageing affects both behavioral and neural processing, emphasizing the importance of large-scale neural recordings.

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Analysis reveals increased neural variability and altered firing rates in older mice, suggesting cognitive decline.

Zang et al. (2025) studied this question.

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