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September 5, 2025Advanced Chinese MedicineOpen Access

Identification and functional characterization of EFNA3 as a dual diagnostic biomarker and immune therapeutic target in rectal cancer

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Authors

TLTianqi LiuJFJiuyuan FangBLBohan Liu

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Overview

Integrative analysis highlights EFNA3's role in tumor progression and immune evasion in rectal cancer, suggesting therapeutic strategies.

Key Points

  • EFNA3 functions as a dual biomarker affecting both prognosis and immunological response in rectal cancer.
  • Elevated EFNA3 expression in rectal adenocarcinoma correlated with poor patient outcomes and reduced immune cell activity.
  • Observational analysis employing multi-omics approaches reveals significant pathways involving EFNA3 in cancer development.
  • Targeting EFNA3 may enhance therapeutic responses, combining PI3K/AKT/mTOR inhibition with immunotherapy for improving patient treatment.

Cite This Study

Liu et al. (2025) studied this question.

synapsesocial.com/papers/68bb3d4e2b87ece8dc955d61https://doi.org/10.1002/acm4.36
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