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September 5, 2025Organic & Biomolecular Chemistry

Rhodium(II) catalysed highly diastereoselective synthesis of indolyl-pyrrolo2,1-aisoindoles from phthalimide derived N-sulfonyl-1,2,3-triazoles and indoles

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Authors

SPSwapnil PatilBBBhalchandra M. BhanageAVAjay Verma

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Overview

A synthetic method demonstrates diastereoselective synthesis of indolyl-pyrrolo[2,1-a]isoindoles from N-sulfonyl-1,2,3-triazoles and indoles, indicating an efficient catalytic process.

Key Points

  • The method achieves high diastereoselectivity in synthesizing indolyl-pyrrolo[2,1-a]isoindoles.
  • Utilizing rhodium as a catalyst, the process involves ring chain isomerization of triazole intermediates.
  • The reaction showcases the versatility of phthalimide derived N-sulfonyl-1,2,3-triazoles.
  • This domino synthesis could lead to new pathways in indole chemistries.

Cite This Study

Patil et al. (2025) studied this question.

synapsesocial.com/papers/68bb3ef72b87ece8dc95780fhttps://doi.org/10.1039/d5ob01295c
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