The role and clinical value of natriuretic peptide receptor family in malignant tumor

The natriuretic peptide receptor (NPR) family (NPRA, NPRB, NPRC) regulates diverse physiological and pathological processes. Mounting evidence implicates NPRs as key regulators of oncogenesis, metastasis, and therapy resistance in multiple cancers. This review integrates current understanding of the distinct mechanisms by which NPR members contribute to cancer development and progression, explores their molecular underpinnings, and discusses translational potential and future directions. A central focus is the context-dependent functional duality of NPR signaling, where specific subtypes act as either oncogenic drivers or tumor suppressors depending on the malignancy.