What does this research mean for the field?

Natriuretic peptide receptor A (NPR-A) plays a critical role in tumorigenesis and represents a viable novel biomarker and therapeutic target for cancer. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 3, 2014World Journal of Surgical OncologyOpen Access

Natriuretic peptide receptor A as a novel target for cancer

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Population

Preclinical cancer models and cancer cell lines

Design

Review

Authors

JZJia ZhangNankai University ZZZhilong ZhaoLinyi University JWJiansheng WangNorth China University of Science and Technology

Discussion

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Implication

Preclinical NPR-A findings warrant no clinical adoption yet; leaves open therapeutic translation pending human trials.

Structured PICO

Population

Preclinical cancer models (C57BL/6 mice, nude mice, BALB/c mice) and cancer cell lines (lung, prostate, ovarian, melanoma)

Intervention

NPR-A deficiency, nanoparticle-formulated interfering RNA for NPR-A, or plasmid encoding NP73-102

Outcome

Tumorigenesis, tumor growth, and metastasis

This review highlights the role of the cardiac hormone receptor NPR-A in tumorigenesis, suggesting it as a novel target for cancer therapy.

Cite This Study

Zhang et al. (2014) studied this question.

synapsesocial.com/papers/6a1e6d025a76b87e0995293d https://doi.org/10.1186/1477-7819-12-174

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Natriuretic peptide receptor A as a novel target for cancer

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Natriuretic peptide receptor A as a novel target for cancer

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider