Why the study?
Does ANP prevent agonist-induced pulmonary edema in mice lacking NPR-A?
Population
NPR-A wild-type, heterozygous, and knockout mice and isolated pulmonary microvascular endothelial cells
Comparison
Atrial natriuretic peptide infusion or… vs Saline vehicle prior to TRAP or LPS
Design
Preclinical
Follow-up
30 min after TRAP or 4 hours after LPS
Authors
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ANP may protect lung barrier function independently of NPR-A; leaves open NPR-C mediation and precludes clinical translation from this animal model.
Does ANP prevent agonist-induced pulmonary edema in mice lacking NPR-A?
ANP attenuates agonist-induced lung edema and pulmonary barrier dysfunction even in the absence of NPR-A, suggesting the protective effect may be mediated by NPR-C.
Klinger et al. (2012) studied this question.