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September 5, 2025ACS Applied Materials & InterfacesOpen Access

Biomimetic Enamel-like Crystals: A Versatile Platform for Unraveling the Basic Mechanisms of Demineralization and Remineralization

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Authors

JCJinke ChangMTMahdi TavakolCBCyril Besnard

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Overview

This study identifies the role of hydroxyapatite in enamel restoration, revealing insights about demineralization and remineralization processes.

Key Points

  • Direct imaging of demineralization and remineralization was achieved using atomic force microscopy for the first time.
  • The study demonstrated that the substitution rate of fluorine in hydroxyapatite affects its stability and reactivity.
  • A facile synthesis method for fluoridated hydroxyapatite nanocrystals was developed for in situ observation.
  • Findings suggest a novel biomimetic approach for enhancing enamel restoration techniques through improved understanding of mineral dynamics.

Cite This Study

Chang et al. (2025) studied this question.

synapsesocial.com/papers/68bb421a2b87ece8dc958681https://doi.org/10.1021/acsami.5c13544
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Electric Field-Guided Biomimetic Mineralization of Enamel via Interfacial Engineering of Nanostructured HAp/PDA Coatings with Anisotropy and Enhanced Hardness2026
  2. 2Enhanced enamel remineralization by a nanohydroxyapatite-fluoride biomimetic formulation: a comparative in vitro study2026
  3. 3Amelogenin-inspired peptide, calcium phosphate solution, fluoride and their synergistic effect on enamel biomimetic remineralization: an in vitro pH-cycling model2024 · 6 citations
  4. 4A MOF‐based Core–Shell System Enables Controlled Release and Ordered Assembly of Nano‐Hydroxyapatite for Enamel Remineralization2025
  5. 5A MOF‐based Core–Shell System Enables Controlled Release and Ordered Assembly of Nano‐Hydroxyapatite for Enamel Remineralization2025