Figure 4 from Characterization of Mutational Signatures in Tumors from a Large Chinese Population

SBS4 activity associated with sex but not smoking status in LUAD. A, SBS4 activity was predominantly observed in lung cancers, including LUAD, LUSC, and SCLC. Each stacked bar represents the estimated activity levels of each signature in each tumor. Signatures with no estimated activity in these tumor types were excluded. B, SBS4 activity was compared between three major types of lung cancer using the Wilcoxon rank-sum test. LUAD had significantly lower SBS4 activity than LUSC. C, The relationship between smoking status, sex, and EGFR mutation status is shown for a subset of LUADs with complete clinical information (n = 271). A higher proportion of males were observed in smokers compared with nonsmokers, and a higher proportion of EGFR mutations were observed in females compared with males in both smokers and nonsmokers. D, Using a Wilcoxon rank-sum test, SBS4 activity was significantly higher in males compared with females in both smokers and nonsmokers but was not significantly different between smokers and nonsmokers within males or within females. E, Using a multivariate linear model, SBS4 activity was associated with sex, sample type (i.e., lower in metastasis compared with primary), EGFR mutation status, and age. CI, confidence interval.