Figure 2 from Characterization of Mutational Signatures in Tumors from a Large Chinese Population

Prevalence of aristolochic acid (SBS22) activity across tumor types. A, SBS22 reflects exposure to aristolochic acid and was highly active in 32 liver carcinomas/HCCs, six intra- or extrahepatic cholangiocarcinomas, three kidney renal cell carcinomas, and five urothelial carcinomas. This signature was also detected in four soft-tissue sarcomas and one esophageal carcinoma, which has not been reported in American and European cohorts. Each bar represents the level of the estimated signature activities in each sample, and samples are ordered by the level of SBS22. B, Using a multivariate linear model, SBS22 activity was associated with sex in urothelial carcinoma. C, SBS22 activity levels in urothelial carcinoma were higher in females compared with males. D, Mutation counts for two example liver carcinomas/HCCs, three soft-tissue sarcomas, and one esophageal carcinoma that predominantly contain the SBS22 signature. CI, confidence interval.