Figure 5 from Characterization of Mutational Signatures in Tumors from a Large Chinese Population

Lower activity of UV-associated mutations in cutaneous melanomas from Chinese patients. A, Bar plot of signature activities for seven melanomas in the OM cohort with at least 10 mutations that were included in the mutational signature analysis. B, The total number of SBS mutations per megabase (Mb), (C) the fraction of C>T mutations, and (D) the fraction of C>T mutations at the TCA, CCC, or TCT trinucleotide contexts were significantly lower in cutaneous melanomas from the Chinese cohort compared with cutaneous melanomas from the American cohort.