Figure 3 from Characterization of Mutational Signatures in Tumors from a Large Chinese Population

Comparison of signature detection and activity levels across populations. A, Signatures with at least 10 counts in a tumor were considered detected in that tumor. The frequencies of detected signatures were compared across Chinese (OM) and American (MSK) cohorts using Fisher’s exact test with an FDR correction. Only tumor types with at least five tumors in each cohort were included. The majority of signature detection rates were not significantly different between cohorts, with the exception of the UV-associated signature SBS7, which was found in a higher proportion of soft-tissue sarcomas in the MSK cohort compared with the OM cohort. B, The median levels of proportional signature activities were compared for matched tumor types between the Chinese (OM) and American (MSK) cohorts using a Wilcoxon rank-sum test with an FDR correction. The majority of signature activities were not significantly different between cohorts with the exception of the apolipoprotein B mRNA editing catalytic polypeptide-like SBS2 signature in breast carcinoma, the SBS6 signature in colorectal carcinoma, and the SBS5 signature in HCC.