August 2, 2025

Supplementary Fig.S22 from Comprehensive Characterization of Somatic Mutation Timing Reveals the Evolutionary Trajectory of Lung Adenocarcinoma in Chinese Patients

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MAIN FINDING: The study identifies various mutational signatures in lung adenocarcinoma specific to Chinese patients.
KEY EVIDENCE: It shows the proportion of multi-base substitutions changes over different mutation periods.
APPROACH: Comprehensive characterization focused on somatic mutations in lung adenocarcinoma tissues.
SIGNIFICANCE: Understanding these evolutionary trajectories may inform future cancer therapies and prevention strategies.

Implication

Comprehensive analysis reveals evolution of lung adenocarcinoma in Chinese patients, indicating distinct mutational patterns.

The proportion of different mutational signatures that underlie the multi-base substitutions (MBS) over different mutation periods.

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Qin et al. (2025) studied this question.

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Comprehensive analysis reveals evolution of lung adenocarcinoma in Chinese patients, indicating distinct mutational patterns.

The proportion of different mutational signatures that underlie the multi-base substitutions (MBS) over different mutation periods.